Most Blessed Sacrament Catholic School, having met the requirements established by the AdvancED® Accreditation Commission and Board of Trustees, is accredited by the Southern Association of Colleges and Schools Council on Accreditation and School Improvement. AdvanceED is "a single, comprehensive organization dedicated to advancing the quality of education for students worldwide." The parochial, inter-parochial, and diocesan schools in the Diocese of Baton Rouge are accredited by AdvanceED as a district. Originally granted district accreditation in February of 2011, the Diocese of Baton Rouge went through re-accreditation in January of 2016.
Most Blessed Sacrament Catholic School received accreditation for the National Blue Ribbon Schools Program in 2013. This program recognizes public schools, charter schools, magnet schools, and non-public schools including parochial and independent schools based on their overall academic excellence. According to the National Blue Ribbon School program, this award "affirms the hard work of students, educators, families, and communities in creating safe and welcoming schools where students master challenging content."